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PHYSICS | 1st PUC | LAB | SPRING CONSTANT | EXP 04

Full Gameplay Part 1 of Slime Rancher 2! Watch me squish slimes! More to come, please SUBSCRIBE LIKE COMMENT!
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This back to school video tutorial is for students who are taking algebra 1, algebra 2, or any higher level course that builds on the basics of algebra such as trigonometry, precalculus, calculus, and so forth.  

Here is a list of topics:
1.  Review of Fractions
2.  Adding and Subtracting Fractions
3.  Multiplying and Dividing Fractions
4.  Properties of Exponents and Powers
5.  Simplifying Algebraic Expressions
6.  Combining Like Terms
7.  Multiplying and Dividing Monomials
8.  Distributive Property and Foil Method
9.  Foiling Binomials and Trinomials
10.  Solving Basic Linear Equations
11.  How to Solve Equations With Variables and Parentheses on Both Sides
12.  Graphing Inequalities on a Number Line
13.  Solving Linear Inequalities 
14.  Solving Equations With Fractions and Decimals

Pre-Algebra Video Playlist:
https://www.youtube.com/watch?v=WJqw-cxvKgo&list=PL0o_zxa4K1BVoTlaXWFcFZ7fU3RvmFMMG

Algebra Review

Steve Yanovsky (RN, Rt-R, EMT-P, CRCST, CIS, CER, CHL) explains the department of sterile processing in detail. Great for CRCST, CIS, CER, CHL. 
If you want to understand the how's and the why's of sterile processing, this is a great place to start.

sterile processing department explained

Dr Sanil Rege discusses strategies to taper antidepressants to prevent or minimise a withdrawal (discontinuation) syndrome. 

Dr Sanil Rege is a Consultant Psychiatrist; founder of Psychscene.com and Vita Health Care. 

Prevalence rates range between 7% and 23% of patients. However, a recent systematic review reported that up to 56% of patients would experience Discontinuation and withdrawal symptoms (DaWS). Of these, almost half (46%; based on four surveys) will regard their severe symptoms.

The neurobiological mechanisms of withdrawal are related to the receptor-rebound phenomenon whereby the sudden discontinuation of medication affects several feedback mechanisms that control serotonin neurotransmission.

Withdrawal symptoms: 

a. Somatic symptoms – Malaise, dizziness, light-headedness, vertigo, paresthesias, fatigue, headache, nausea, tremor, muscle spasms, diarrhoea, sweating, and hallucinations
b. Psychological symptoms - Anxiety, insomnia, emotional blunting, and irritability

DaWS are diverse and variably expressed; the acronym FINISH – Flu-like symptoms; Insomnia; Nausea; Imbalance; Sensory disturbances; Hyperarousal is a useful guide for assessing the domains affected.

Mitigation of withdrawal symptoms with SSRIs (selective serotonin reuptake inhibitor) and other antidepressants can be achieved through carefully tapered discontinuation due to the hyperbolic relationship between drug dose and activity.

The principle behind the tapered discontinuation is based on the law of mass action. There is a steep increase in effect at small doses of the drug, flattening out as receptors become increasingly saturated.

Tapers over a period of months and down to doses much lower than minimum therapeutic doses have shown greater success in reducing withdrawal symptoms.

Therefore, when tapering antidepressants, clinicians are suggested to follow a regimen that focuses on biological effect (e.g. SERT occupancy) rather than arbitrarily withdrawing medication using a linear stepwise approach. From a practical viewpoint, it may be necessary to switch to liquid formulations given the requirement for micro-modifications of dose during the later tapering stages.

Dose effects are important; using citalopram as an example, halving the dose from 60 mg to 30 mg reduces the pharmacological activity at the SERT transporter only by a couple of percentage points.

Dose reductions at the bottom end of the dose range have a much larger effect, and this is where care is needed. Antipsychotics show a similar phenomenon.

References: 

Horowitz A and Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. Lancet Psychiatry. 2019;6(7):561-562. 
Malhi, G.S., Bell, E., Bassett, D., Boyce, P., Bryant, R., Hazell, P., Hopwood, M., Lyndon, B., Mulder, R., Porter, R. and Singh, A.B., 2021. The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Australian & New Zealand Journal of Psychiatry, 55(1), pp.7-117.

How to Taper Antidepressants to Avoid a Withdrawal (Discontinuation) Syndrome?

If you want to listen to New Thinking or any other audiobooks, go to https://audible.com/coldfusion 
or text coldfusion to 500 500 for a 30 day free trial!

Carbon nanotubes sound like something out of science fiction movie, but their slowly starting to find uses in our lives. Today we'll look at how they're being used to fight heart disease.

Previous video for Nanobots and cancer: https://www.youtube.com/watch?v=Cg--UVL9xCc

--- About ColdFusion ---
ColdFusion is an Australian based online media company independently run by Dagogo Altraide since 2009. Topics cover anything in science, technology, history and business in a calm and relaxed environment. 

If you enjoy my content, please consider subscribing!
I'm also on Patreon: https://www.patreon.com/ColdFusion_TV
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Sources:

https://www.nature.com/articles/s41565-019-0619-3.epdf?no_publisher_access=1&r3_referer=nature

https://www.digitaltrends.com/cool-tech/nanoparticle-eats-plaque-heart-attack/

https://med.stanford.edu/news/all-news/2020/01/nanotherapy-reduces-plaque-buildup-in-mouse-arteries.html

https://www.nhlbi.nih.gov/health-topics/atherosclerosis


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4th Front - For Us

Tom Demac & Real Lies - White Flowers

Great Skies - Infinite (Extended Version)

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Producer: Dagogo Altraide

Breakthrough: Nanoparticle Eats Plaque Responsible for Heart Attacks

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THE ALL KURIBOH DECK!! Today in master duel we are paying respect to one of the most iconic monsters in the entire Yu-Gi-Oh! franchise. Kuriboh! Will an entire deck based around kuriboh be able to compte in Yu-Gi-Oh! Master Duel! ranked matches!

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Yu-Gi-Oh! Master Duel ranked gameplay and commentary!

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